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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Renal cell carcinoma metastasis without a primary: A case report
Basil Razi1, Dane Cole-Clark1, Duncan Self1
1Department of Urology, Gosford Hospital, Gosford, NSW, Australia.
Urology Case Reports
|February 13, 2024
Summary
A rare case of metastatic renal cell carcinoma (RCC) was found in a lymph node without an identifiable primary tumor. This patient remains cancer-free 15 months post-surgery, highlighting an unusual presentation of kidney cancer.
Area of Science:
- Oncology
- Urology
Background:
- Renal Cell Carcinoma (RCC) accounts for 90% of primary renal malignancies in Australia.
- RCC is often slow-growing, asymptomatic, and incidentally discovered.
- Metastatic presentation of RCC without a detectable primary tumor is exceptionally rare.
Observation:
- A 76-year-old male presented with a metastatic RCC in a para-aortic lymph node.
- No primary renal malignancy was identified in the patient.
- The patient underwent a retroperitoneal lymphadenectomy.
Findings:
- The patient showed no signs of primary tumors or metastasis 15 months after surgery.
- This case represents a rare instance of metastatic RCC without an identified primary lesion.
Implications:
- This case challenges typical diagnostic pathways for metastatic kidney cancer.
- Further investigation into rare presentations of RCC may improve early detection and treatment strategies.
- Highlights the importance of considering metastatic disease even when primary tumors are occult.
