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Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis

Thalys Sampaio Rodrigues1, Levindo Jose Garcia Quarto2, Savio Carvalho Nogueira3

  • 1Department of Cardiology, Austin Health, Melbourne, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

American Heart Journal
|February 15, 2024
PubMed

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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