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Updated: Jul 3, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Immunotherapy-induced adverse events in metastatic renal cell carcinoma: A case of rapid response and complex
João Pedroso Lima1, Ana Marta Ferreira1, Vasco Quaresma1
1Urology and Renal Transplantation Department, Hospital and University Centre of Coimbra, Praceta Professor Mota Pinto, 3004-561, Coimbra, Portugal.
Abstract:
A 55-year-old woman with dyspnea was diagnosed with a 9.5cm left renal clear cell carcinoma and extensive metastatic disease. Initial treatment with Sunitinib was effective but discontinued due to severe dermatitis. Nivolumab therapy led to complete metastasis resolution and consequently nephrectomy was performed at 12 months. Postoperatively, she developed Vogt-Koyanagi-Harada-like disease, necessitating Nivolumab suspension and vision improvement with corticosteroids. After 24 disease-free months, a new contralateral renal lesion and pulmonary metastases were identified, prompting cabozantinib treatment. This resulted in clinical improvement and a partial response at the first follow-up.
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