Signal transduction interfaces for field-effect transistor-based biosensors
1Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. sakata@biofet.t.u-tokyo.ac.jp.
Communications Chemistry
|February 19, 2024
Summary
Field-effect transistor (FET) biosensors offer cost-effective healthcare solutions. This review details signal transduction interfaces crucial for FET biosensor performance and specificity.
Area of Science:
- Biomedical Engineering
- Materials Science
- Analytical Chemistry
Background:
- Field-effect transistor (FET) biosensors are promising for miniaturized, cost-effective healthcare applications.
- Diverse semiconductive materials, including 1D and 2D materials, are utilized as FET channels for biosensing.
- The signal transduction interface is critical for converting biological events into measurable electrical signals.
Purpose of the Study:
- To review and categorize distinctive signal transduction interfaces for FET biosensors.
- To highlight the role of these interfaces in controlling key biosensing parameters.
Main Methods:
- Categorization of signal transduction interfaces into chemically synthesized, physically structured, and biologically induced types.
- Analysis of how interface design impacts biosensor performance.
Main Results:
- Distinct signal transduction interfaces significantly influence biosensing parameters.
- Interface characteristics directly affect specificity, selectivity, binding constant, limit of detection, signal-to-noise ratio, and biocompatibility.
Conclusions:
- Signal transduction interfaces are pivotal in optimizing FET biosensor capabilities.
- Tailoring interfaces is essential for advancing sensitive and selective biosensing technologies for healthcare.
