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Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity

XueJun Deng1, Kai Tang1, Zhiqiang Wang2

  • 1Department of Cardiology, Suining Central Hospital, Suining, 629000, Sichuan, China.

Journal of Epidemiology and Global Health
|February 20, 2024
PubMed

Insights

Genetic variants in pro-inflammatory cytokines impact COVID-19 outcomes. The rs1800629 variant is linked to increased severity and mortality, while rs1800795 affects susceptibility.

Area of Science:

  • Immunogenetics
  • Infectious Disease Epidemiology
  • Molecular Biology

Background:

  • Cytokine storm significantly impacts COVID-19 prognosis.
  • Pro-inflammatory cytokine gene variants are associated with cytokine storm.
  • This study investigates if cytokine variants modulate COVID-19 outcomes via cytokine storm.

Purpose of the Study:

  • To verify the hypothesis that pro-inflammatory cytokine variants impact COVID-19 outcomes.
  • To analyze the association of specific cytokine gene variants (rs1800795, rs1800629) with COVID-19 clinical outcomes.
  • To explore the relationship between these variants and inflammatory markers.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov until December 15, 2023.
  • Case-control and cohort studies examining the impacts of rs1800795 or rs1800629 on COVID-19 susceptibility, severity, mortality, IL-6, TNF-α, or CRP levels were included.
  • Data were analyzed following an anonymous review process by independent reviewers.

Main Results:

  • Analysis included 47 studies with 8305 COVID-19 patients and 17,846 controls.
  • The rs1800629 A allele correlated with higher TNF-α and CRP levels, and increased COVID-19 severity and mortality.
  • The rs1800795 C allele was linked to higher IL-6 and CRP levels, and increased COVID-19 susceptibility.

Conclusions:

  • Pro-inflammatory cytokine variants rs1800629 and rs1800795 significantly influence systemic inflammation and COVID-19 outcomes.
  • The rs1800629 variant shows potential as a genetic marker for severe COVID-19.
  • These findings highlight the role of genetic factors in COVID-19 pathogenesis and prognosis.
Abstract

Keywords:
Coronavirus disease 2019Cytokine stormIL-6Severity

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