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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Related Experiment Video

Updated: Jul 2, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Epigenetics as a Key Factor in Prostate Cancer.

Kadriia Enikeeva1, Guzel Rafikova1, Yuliya Sharifyanova1

  • 1Institute of Urology and Clinical Oncology, Bashkir State Medical University, Ufa, 450008, Russia.

Advanced Biology
|February 21, 2024
PubMed
Summary

Epigenetic alterations in prostate cancer offer new hope for early detection and personalized treatment strategies. Targeting these changes, like CpG island methylation and microRNAs, can improve therapeutic effectiveness and predict patient outcomes.

Keywords:
predictive epigenetic biomarkersprostate cancer epigeneticprostate cancer treatment

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

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Related Experiment Videos

Last Updated: Jul 2, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cause of cancer-related deaths in men globally.
  • Current treatment strategies are often inadequate, leading to high mortality rates.
  • Early detection and improved therapeutic approaches are crucial for managing prostate cancer.

Purpose of the Study:

  • To highlight the significance of epigenetic regulation in prostate cancer development.
  • To explore the potential of epigenetic alterations as early diagnostic biomarkers.
  • To investigate epigenetic modifications as targets for personalized prostate cancer therapy.

Main Methods:

  • Review of molecular genetic studies on epigenetic regulation in cancer.
  • Analysis of epigenetic aberrations, including CpG island methylation, histone modification, and microRNAs.
  • Correlation of epigenetic changes with drug resistance and therapeutic effects.

Main Results:

  • Epigenetic changes are detectable at the earliest stages of prostate cancer.
  • Epigenetic aberrations in tumor tissue are linked to drug resistance.
  • Specific epigenetic alterations show promise as diagnostic biomarkers.

Conclusions:

  • Epigenetic alterations are critical in prostate cancer development and progression.
  • Targeting epigenetic modifications can lead to more personalized and effective prostate cancer treatments.
  • Biomarkers such as CpG island methylation and microRNAs can enhance disease diagnosis and treatment prediction.