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Updated: Jul 2, 2025

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
Published on: February 23, 2017
Conformational Locking as a Strategy to Reverse Ion Recognition Selectivity
Wei Zhang1,2, Chong Zhao3, Wenjie Zhu2
1College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, China.
Abstract:
This study delves into the ion recognition capabilities of a novel host molecule, emphasizing the role of conformational locking in dictating ion selectivity. By employing the Buchwald-Hartwig cross-coupling reaction, we have notably shifted the ion receptor's selectivity from K+ to Na+. The findings are supported by computational simulations that reveal differences in binding energies and molecular strain impacting ion recognition. This innovative structural modification broadens the scope for alterations at the calix[4]arene's lower rim, paving the way for new methods and strategies in modulating ion recognition selectivity.
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