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Leumorphin in human brain.

M Suda, K Nakao, M Sakamoto

    Neuropeptides
    |February 1, 1985
    PubMed
    Summary
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    Leumorphin, a potential opioid peptide, has been identified in the human brain. This novel endogenous opioid peptide is found alongside dynorphin B, indicating a significant discovery in human neurochemistry.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Molecular Biology

    Background:

    • Porcine leumorphin, an opioid peptide from preproenkephalin B, exists in pigs.
    • Human preproenkephalin B differs by 3 amino acids from the porcine version.
    • The presence of leumorphin in humans remains unconfirmed.

    Purpose of the Study:

    • To determine if leumorphin is an endogenous opioid peptide in humans.
    • To investigate the regional distribution of leumorphin in the human brain.

    Main Methods:

    • Radioimmunoassay (RIA) for leumorphin.
    • Reverse-phase High-Performance Liquid Chromatography (HPLC).
    • High-performance gel permeation chromatography (HPGPC).

    Main Results:

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    • Human leumorphin was detected in water extracts of the human brain.
    • Leumorphin co-existed with rimorphin (dynorphin B).
    • Leumorphin-like immunoreactivity and dynorphin-like immunoreactivity showed parallel distribution in the brain.

    Conclusions:

    • Leumorphin is identified as a novel endogenous opioid peptide in humans.
    • The findings suggest a role for leumorphin in human neurobiology.
    • Further research into leumorphin's function is warranted.