Related Experiment Video
Updated: Jul 2, 2025
07:42
Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
317
The Interplay between Mycobacterium tuberculosis and Human Microbiome
Michelle Nguyen1, Phillip Ahn1, John Dawi1
1College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Clinics and Practice
|February 23, 2024
Summary
Tuberculosis (TB) lung infections are impacted by the microbiome. Altering the gut-lung axis may offer new treatments for drug-resistant TB.
Area of Science:
- Microbiology
- Immunology
- Pulmonology
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a leading global cause of death.
- The lung microbiome plays a crucial role in immune system development and host defense.
- Mtb infection and antibiotic treatments can disrupt the lung microbiome, leading to dysbiosis and weakened immunity.
Purpose of the Study:
- To explore the role of the human microbiome in tuberculosis pathogenesis.
- To investigate the potential of targeting the gut-lung axis for TB treatment.
- To address challenges posed by drug-resistant TB.
Main Methods:
- Review of current research on the human microbiome and TB.
- Analysis of the impact of Mtb infection and antibiotics on the lung microbial profile.
- Exploration of the gut-lung bacterial axis.
Main Results:
- The lung is not sterile and harbors a unique microbiome crucial for immunity.
- Dysbiosis, induced by Mtb or antibiotics, impairs host immune response.
- Drug-resistant TB necessitates novel therapeutic strategies.
Conclusions:
- The human microbiome significantly influences TB development and progression.
- Modulating the gut-lung axis presents a promising avenue for combating drug-resistant TB.
- Targeting microbial communities may mitigate the impact of tuberculosis.
Related Concept Videos
01:29Pulmonary Tuberculosis I
243
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
243
01:28Pulmonary Tuberculosis II
236
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
236
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:26Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
01:31Pulmonary Tuberculosis III
326
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
326
01:28Pulmonary Tuberculosis V
180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180