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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

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Published on: October 29, 2015

Selected Milestones in Antiviral Drug Development

Erik De Clercq¹

¹Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.

|February 24, 2024

Abstract:

This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase inhibitors), NtRTIs (nucleotide reverse transcriptase inhibitors) and NNRTIs (non-nucleoside reverse transcriptase inhibitors) as HIV inhibitors, (iv) NtRTIs as HBV inhibitors, and finally, (v) the transition of an HIV inhibitor to a stem cell mobilizer, as exemplified by AMD-3100 (Mozobil^®).

Keywords:

AIDS ANPs CMV HBV HIV HSV NNRTIs NRTIs NtRTIs VSV

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