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Immuno-Oncology: New Insights into Targets and Therapies

Shiruyeh Schokrpur1, Michael G White2, Christina L Roland3

  • 1Division of Hematology/Oncology, Department of Medicine, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92037, USA.

Surgical Oncology Clinics of North America
|February 24, 2024
PubMed

The role of immunotherapy in the care of surgical oncology patients promises to expand as investigators and clinicians evaluate new targets and approaches. Currently active clinical trials evaluate new immune checkpoints, including lymphocyte activation gene 3, T cell immunoreceptor with Ig and ITIM domains, and killer Ig-like receptor 2DL1/2L3. Vaccines delivered through mRNA have demonstrated exciting results in early clinical trials and hold promise for expanded application. Investigational approaches include dendritic cell vaccines, peptide vaccines, cytokines therapies, and cellular therapies. These studies have the potential to revolutionize the management of surgical oncology patients and promote durable cures following surgical resection.

Keywords:
Cancer vaccineCytokine therapyImmunotherapyPerioperative therapyViral therapy

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