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Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery
Hannah G McDonald1, Daniel M Kerekes2, Joseph Kim1
1Department of General Surgery, Division of Surgical Oncology, The University of Kentucky, 800 Rose Street, Lexington, KY 40508, USA.
Abstract:
Precision medicine is used to treat gastrointestinal malignancies including esophageal, gastric, small bowel, colorectal, and pancreatic cancers. Cutting-edge assays to detect and treat these cancers are active areas of research and will soon become standard of care. Colorectal cancer is a prime example of precision oncology as disease site is no longer the final determinate of treatment. Here, the authors describe how leveraging an understanding of tumor biology translates to individualized patient care using evidence-based practices.
Insights
Precision medicine revolutionizes gastrointestinal cancer treatment, including colorectal cancer. Understanding tumor biology enables individualized patient care through evidence-based practices.
Area of Science:
- Oncology
- Gastroenterology
- Genomics
Background:
- Precision medicine is increasingly vital for treating gastrointestinal malignancies.
- Esophageal, gastric, small bowel, colorectal, and pancreatic cancers are key targets.
- Advanced detection and treatment assays are rapidly evolving towards standard care.
Purpose of the Study:
- To describe how understanding tumor biology informs individualized patient care in gastrointestinal oncology.
- To highlight colorectal cancer as a model for precision oncology.
- To emphasize the shift from disease site to molecular characteristics in treatment decisions.
Main Methods:
- Review of current research in precision medicine for gastrointestinal cancers.
- Analysis of how tumor biology data translates to clinical practice.
- Focus on evidence-based approaches for personalized treatment.
Main Results:
- Colorectal cancer exemplifies precision oncology, where treatment is not solely determined by cancer location.
- Leveraging tumor biology allows for tailored therapeutic strategies.
- Individualized patient care is enhanced through molecular insights.
Conclusions:
- Precision medicine, driven by tumor biology, is transforming gastrointestinal cancer care.
- Evidence-based practices are crucial for implementing personalized oncology.
- Future cancer treatment will increasingly rely on molecular profiling for targeted therapies.
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