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Prospective Associations of Accelerometer-Measured Machine-Learned Sedentary Behavior With Death Among Older Women:
Steve Nguyen1, John Bellettiere1, Blake Anuskiewicz1
1Division of Epidemiology Herbert Wertheim School of Public Health, University of California San Diego La Jolla CA USA.
Journal of the American Heart Association
|February 27, 2024
Summary
Increased sitting time and longer sitting bouts are linked to higher mortality risks in older women. Reducing sedentary behavior and breaking up prolonged sitting may improve health outcomes.
Area of Science:
- Gerontology
- Public Health
- Biostatistics
Background:
- Sedentary behavior is a significant risk factor for mortality.
- A novel convolutional neural network (CNN) algorithm accurately classifies sitting time and posture from hip accelerometer data.
- This study investigates the link between sedentary behavior metrics and mortality.
Purpose of the Study:
- To examine the prospective associations between CNN-classified total sitting time and mean sitting bout duration with all-cause and cardiovascular disease (CVD) mortality.
- To assess the risk associated with different levels of sedentary behavior in older women.
Main Methods:
- Utilized data from 5856 women in the Women's Health Initiative Objective Physical Activity and Cardiovascular Health (OPACH) Study.
- Participants wore hip accelerometers (ActiGraph GT3X+) for ~7 days to collect data.
- Follow-up data through February 19, 2022, was used to track all-cause and CVD deaths.
Main Results:
- Higher total sitting time (quartile >696 min/d) was associated with increased all-cause (HR 1.57) and CVD mortality (HR 1.78).
- Longer mean sitting bout duration (quartile >15 min) was linked to higher all-cause (HR 1.43) and CVD mortality (HR 1.52).
- Nonlinear associations indicated elevated risk after approximately 660-700 minutes of sitting per day.
Conclusions:
- Higher total sitting time and longer sitting bout durations are associated with increased mortality risk in older women.
- Interventions targeting reduction of total sitting time and interruption of prolonged sitting are supported by these findings.
- These results highlight the importance of addressing sedentary behavior in older adult populations.

