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Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A
Maryam Motamedinasab1,2, Mojgan Karimi-Zarchi3, Zahra Marzbanrad1
1Department of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Asian Pacific Journal of Cancer Prevention : APJCP
|February 28, 2024
Summary
The Tumor Protein TP73 (TP73) G4C14-to-A4T14 polymorphism is not linked to cervical cancer risk globally or in East Asian women. Further research into gene interactions is recommended for a clearer understanding.
Area of Science:
- Genetics and Oncology
- Cancer Susceptibility Research
- Molecular Epidemiology
Background:
- Polymorphisms in Tumor Protein TP73 (TP73) have been linked to cancer susceptibility, particularly gynecological cancers, but findings are inconsistent.
- This meta-analysis investigates the association between the TP73 G4C14-to-A4T14 polymorphism and cervical cancer risk worldwide and across ethnicities.
- Previous studies show conflicting results regarding the role of TP73 polymorphisms in cancer development.
Approach:
- A comprehensive literature search was conducted across major databases (PubMed, Scopus, Web of Science, Embase, Wan Fang, CNKI) for eligible studies published before October 25, 2023.
- Ten case-control studies, including 1804 cervical cancer cases and 2433 controls, were included in the meta-analysis.
- Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association between the TP73 G4C14-to-A4T14 polymorphism and cervical cancer risk.
Key Points:
- The overall meta-analysis found no significant association between the TP73 G4C14-to-A4T14 polymorphism and cervical cancer risk.
- Stratified analysis by ethnicity indicated no association between this polymorphism and cervical cancer risk among East Asian women.
- A significant association was observed in hospital-based studies, suggesting potential influence of study design or control source.
Conclusions:
- The TP73 G4C14-to-A4T14 polymorphism does not appear to be a significant risk factor for cervical cancer globally or in East Asian populations.
- Findings contradict some previous meta-analyses, highlighting the need for careful interpretation of genetic association studies.
- Future research should explore gene-gene and gene-environment interactions to gain a more comprehensive understanding of cervical cancer etiology.
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