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Promising Phytoconstituents in Diabetes-related Wounds: Mechanistic Insights and Implications
Arjina Sultana1, Ranadeep Borgohain2, Ashwini Rayaji3
1Department of Pharmacology, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Azara, Guwahati 781017, Assam, India.
Background:
The onset of diabetes mellitus (DM), a metabolic disorder characterized by high blood glucose levels and disrupted glucose metabolism, results in 20% of people with diabetes suffering from diabetes-related wounds worldwide. A minor wound, such as a cut or abrasion, can lead to infections and complications in diabetic patients. We must understand the mechanism/s contributing to this delayed wound healing to develop effective prevention strategies. The potential benefits of bioactive phytochemicals for diabetic wound healing have been reported in numerous studies.
Method:
A bioactive compound may have multiple actions, including antioxidants, antiinflammatory, antimicrobial, and angiogenesis. Compounds derived from these plants have shown promising results in wound healing, inflammation reduction, collagen synthesis, and neovascularization improvement.
Results:
Consequently, this review provides an update to our understanding of how phytoconstituents promote wound healing in diabetics. A thorough literature review was conducted on diabetes, wound healing, and phytoconstituents for this study. Only English publications until June 2023 were included in the search, which used multiple search engines and the main keywords. Summing up, phytochemical-based interventions might improve the quality of life for diabetics by improving wound healing.
Conclusion:
However, to fully understand the efficacy and safety of these phytochemicals in managing diabetic wounds, more research and clinical trials are needed.
Insights
Bioactive phytochemicals show promise in accelerating wound healing for individuals with diabetes mellitus (DM). Further research is needed to confirm their efficacy and safety in managing diabetic wounds.
Area of Science:
- Integrative medicine
- Pharmacology
- Biochemistry
Background:
- Diabetes mellitus (DM) affects 20% of individuals globally, leading to delayed wound healing and complications.
- Diabetic wounds are susceptible to infections, necessitating effective prevention and treatment strategies.
- Bioactive phytochemicals are increasingly recognized for their therapeutic potential in managing chronic conditions like diabetes.
Purpose of the Study:
- To review the current understanding of how phytoconstituents influence diabetic wound healing.
- To explore the mechanisms by which phytochemicals promote healing in diabetic patients.
- To update knowledge on the role of plant-derived compounds in managing diabetes-related wounds.
Main Methods:
- Comprehensive literature review of studies on diabetes, wound healing, and phytoconstituents.
- Inclusion of English-language publications up to June 2023.
- Utilized multiple search engines with predefined keywords for systematic data retrieval.
Main Results:
- Phytochemicals exhibit multifaceted actions, including antioxidant, anti-inflammatory, antimicrobial, and pro-angiogenic properties.
- Plant-derived compounds have demonstrated significant improvements in wound healing, reduced inflammation, enhanced collagen synthesis, and increased neovascularization.
- Phytochemical interventions may enhance the quality of life for diabetic patients by improving wound healing outcomes.
Conclusions:
- Phytoconstituents hold significant potential for improving diabetic wound healing.
- Further clinical trials and research are essential to validate the efficacy and safety of phytochemicals for diabetic wound management.
- Understanding the precise mechanisms of action is crucial for optimizing phytochemical-based therapeutic strategies.
