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Astrocyte Activation and Drug Target in Pathophysiology of Multiple Sclerosis
Preeti Bisht1, Charul Rathore1, Ankit Rathee1
1University Institute of Pharma Sciences, Chandigarh University, Ajitgarh, Punjab, India.
Methods in Molecular Biology (Clifton, N.J.)
|March 1, 2024
Summary
Multiple sclerosis involves central nervous system demyelination. Astrocytes play a key role in this neurodegenerative disease, influencing both damage and repair, and offering potential therapeutic targets.
Area of Science:
- Neuroimmunology
- Neurodegenerative Diseases
Background:
- Multiple sclerosis (MS) is a chronic inflammatory demyelination disease affecting the central nervous system (CNS).
- Demyelination, the destruction of the myelin sheath, impairs neuronal function and synaptic connections.
- Astrocytes exhibit dual roles in both the demyelination and remyelination processes in MS.
Conclusions:
- Astrocytes present a complex role in MS, acting as both detrimental and beneficial factors in the CNS.
- Further research into astrocyte-targeted therapies holds promise for future MS treatments.
- Understanding astrocyte behavior is crucial for developing effective strategies against MS-induced demyelination.
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