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[Antifungal prophylaxis: up-date and prospectives]
Abstract:
Author reviews the now available strategies for the prophylaxis of primary and opportunistic mycoses. Chemoprophylaxis of opportunistic mycoses that are the most frequently observed fungal infections in Italy, gives satisfactory protection in endogenous fungal infections. On the contrary, fungal exogenous infections are not easily treated. In fact, systematically acting drugs which are also easy to use, are still lacking. Strict reverse isolation seems to achieve good results in these infections.
Insights
Strategies for preventing fungal infections (mycoses) are reviewed. Chemoprophylaxis effectively protects against opportunistic mycoses, particularly endogenous types, but exogenous infections remain challenging to treat, necessitating strict isolation methods.
Area of Science:
- Mycology
- Infectious Diseases
- Pharmacology
Context:
- Opportunistic mycoses are common fungal infections, especially in Italy.
- Endogenous fungal infections show good response to chemoprophylaxis.
- Exogenous fungal infections present treatment challenges due to a lack of effective systemic drugs.
Purpose:
- To review current strategies for the prophylaxis of primary and opportunistic mycoses.
- To evaluate the efficacy of chemoprophylaxis for different types of fungal infections.
- To identify unmet needs in the treatment of exogenous fungal infections.
Summary:
- Chemoprophylaxis provides satisfactory protection against endogenous opportunistic mycoses.
- Systemically acting and user-friendly drugs for exogenous fungal infections are currently unavailable.
- Strict reverse isolation is a recommended approach for managing exogenous fungal infections.
Impact:
- Highlights the limitations of current chemoprophylaxis for certain fungal infections.
- Underscores the need for developing new therapeutic agents for exogenous mycoses.
- Emphasizes the importance of non-pharmacological interventions like reverse isolation.