Related Experiment Video

Updated: Jul 1, 2025

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

18.8K

Stress hyperglycemia ratio linked to worse prognosis in Cardiac Intensive Care Unit patients: A retrospective

Qianqian Zhang1, Huaqiang Xiang1, Qianqian Xu1

  • 1The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Diabetes Research and Clinical Practice
|March 2, 2024
PubMed

Insights

The stress hyperglycemia ratio (SHR) effectively predicts poor outcomes, including mortality and major adverse cardiovascular events (MACEs), in cardiac intensive care unit (CICU) patients. Elevated SHR is a significant risk factor, even in non-diabetic individuals.

Area of Science:

  • Cardiology
  • Intensive Care Medicine
  • Endocrinology

Background:

  • Stress hyperglycemia is common in critically ill patients.
  • The stress hyperglycemia ratio (SHR) is a novel marker potentially reflecting the body's stress response.
  • Predictive markers for outcomes in cardiac intensive care units (CICUs) are crucial for patient management.

Purpose of the Study:

  • To investigate the correlation between the stress hyperglycemia ratio (SHR) and clinical outcomes in patients admitted to the cardiac intensive care unit (CICU).
  • To evaluate SHR's predictive capability for short-term mortality and major adverse cardiovascular events (MACEs).

Main Methods:

  • Patient data from two cohorts were analyzed.
  • Participants were stratified by SHR levels.
  • Inverse probability of treatment weighting (IPTW) and Kaplan-Meier analyses were employed to assess the association between SHR and outcomes.
  • The C-statistic was utilized to evaluate SHR's predictive performance.

Main Results:

  • A total of 1,545 patients were included in the study.
  • Higher SHR levels were associated with increased 90-day mortality and MACEs.
  • Patients with elevated SHR but without diabetes showed the highest mortality and MACE rates.
  • SHR demonstrated strong predictive capability for short-term mortality and MACEs, with a C-statistic of 0.821.

Conclusions:

  • The stress hyperglycemia ratio (SHR) is a valuable and independent predictor of adverse clinical outcomes in CICU patients.
  • SHR can aid in risk stratification and inform prognostic treatment strategies for critically ill cardiac patients.
  • SHR may offer superior predictive value compared to other hyperglycemia metrics.
Abstract

Keywords:
Cardiac intensive care unitClinical outcomesDiabetesStress hyperglycemia ratio

More Related Videos

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

364
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.4K

Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
260
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.0K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
534
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
1.3K