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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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Updated: Jul 1, 2025

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OPTN/SRTR 2022 Annual Data Report: Liver.

Allison J Kwong1, W Ray Kim2, John R Lake3

  • 1Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|March 2, 2024
PubMed
Summary

Liver transplant activity reached an all-time high in 2022, with improved survival rates for deceased and living donor transplants. Despite progress, challenges remain for pediatric liver transplant candidates.

Keywords:
Allocationdistributionliver transplantwaiting list

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Area of Science:

  • Hepatology and Transplant Surgery
  • Organ Transplantation Statistics
  • Public Health and Epidemiology

Background:

  • Liver transplantation is a critical treatment for end-stage liver disease.
  • Transplant activity and outcomes are influenced by donor availability, recipient factors, and disease prevalence.
  • Monitoring trends in liver transplant activity is essential for resource allocation and policy development.

Purpose of the Study:

  • To analyze the trends and outcomes of liver transplantation in the United States in 2022.
  • To compare deceased donor versus living donor liver transplant activity and survival.
  • To evaluate outcomes for adult and pediatric liver transplant recipients, including those with specific conditions like hepatocellular carcinoma.

Main Methods:

  • Analysis of national liver transplant data from 2022, including recipient demographics, donor types, and diagnoses.
  • Comparison of transplant waiting list dynamics, pretransplant mortality, and posttransplant survival rates.
  • Evaluation of outcomes for simultaneous liver-kidney transplants and hepatocellular carcinoma exception cases.

Main Results:

  • A record 9,527 liver transplants were performed in 2022, a 52% increase over the decade, with 93.7% from deceased donors.
  • Alcohol-associated liver disease and metabolic dysfunction-associated steatohepatitis were leading diagnoses; survival rates improved, nearing pre-pandemic levels.
  • Living donor liver transplants showed superior 5-year survival rates in both adult and pediatric recipients compared to deceased donor transplants.

Conclusions:

  • Liver transplant activity and survival outcomes continue to improve, yet significant numbers remain on the waiting list.
  • Living donor liver transplantation offers better long-term survival, highlighting its importance.
  • While pediatric outcomes have improved, challenges persist, with a notable number of children dying or becoming too sick for transplant.