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Tougher Bioadhesives through Dual Stimulation Strategies.

Elwin W J Ang1,2, Ivan Djordjevic2, Ivan Solic2

  • 1Nanyang Environment and Water Research Institute, Interdisciplinary Graduate School, Nanyang Technological University, Singapore, 637553, Singapore.

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|March 3, 2024
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Summary
This summary is machine-generated.

This study introduces a dual activation method for carbene bioadhesives, combining heat and light. This approach significantly enhances adhesive toughness and cohesive properties, offering a promising strategy for improved tissue adhesion materials.

Keywords:
bioadhesivecarbenediazirinedual‐activationnuclear magnetic resonance spectroscopypolycaprolactonerheology

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Adhesive Technology

Background:

  • Carbene-based bioadhesives offer versatile tissue bonding but exhibit limited fracture strength post-photocuring.
  • Photocuring of carbene precursors (diazirines) generates inert byproducts, unlike thermal activation.

Purpose of the Study:

  • To investigate a dual activation method combining light irradiation and elevated temperatures for carbene bioadhesives.
  • To evaluate the impact of this dual activation on diazirine depletion and cohesive properties.
  • To enhance the fracture strength and viscoelastic dissipation of carbene bioadhesives.

Main Methods:

  • A customized photo/thermal-rheometer was employed to assess viscoelastic properties.
  • 19F NMR spectroscopy was used to monitor carbene:diazoalkane ratios and trifluoroaryl diazirine consumption kinetics.
  • Dual thermal and light irradiation was applied to carbene bioadhesives.

Main Results:

  • The combination of heat and photoactivation resulted in bioadhesives that were three times tougher than controls.
  • Dual activation influenced diazirine depletion kinetics and improved cohesive properties.
  • 19F NMR successfully correlated joule-based light/temperature kinetics with trifluoroaryl diazirine consumption.

Conclusions:

  • Dual thermal and light irradiation is an effective strategy to improve the viscoelastic dissipation and toughness of photo-activated adhesive resins.
  • This approach mitigates issues associated with photocuring, such as inert byproduct formation.
  • The findings present a novel method for developing stronger and more robust carbene-based bioadhesives for tissue applications.