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Updated: May 12, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Aldehyde group pendant-grafted pectin-based injectable hydrogel.

De-Qiang Li¹, Maryamgul Tohti¹, Yong-Sheng Fu¹

¹College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumchi 830052, Xinjiang, PR China.

International Journal of Biological Macromolecules

|March 3, 2024

Summary

This summary is machine-generated.

This study introduces a novel method to create aldehyde group-functionalized polysaccharides, preserving their structure for advanced applications like injectable hydrogels. These hydrogels demonstrate excellent properties and biocompatibility for drug delivery.

Keywords:

Chemical modification Drug delivery Imine bonds Injectability Pectin Self-healing

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Materials Science
Biotechnology
Polymer Chemistry

Background:

Traditional periodate oxidation for aldehyde-functionalized polysaccharides causes backbone ring opening, altering physicochemical properties.
A need exists for methods preserving polysaccharide backbone integrity for improved material performance.

Purpose of the Study:

To develop a novel method for aldehyde group-functionalized polysaccharides that retains the native ring structure.
To prepare an injectable hydrogel from modified pectin for potential drug release applications.

Main Methods:

Pectin was modified with cyclopropyl formaldehyde to yield pectin aldehyde (AP).
AP was crosslinked with DL-lysine (LYS) via Schiff base reaction to form injectable hydrogels.
Fourier-transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (¹H NMR) confirmed functionalization.

Main Results:

The novel method successfully functionalized pectin while preserving the backbone's ring structure.
The resulting injectable hydrogel exhibited favorable mechanical properties, self-healing, syringeability, and sustained release.
The hydrogel demonstrated excellent biocompatibility (96% cell proliferation) and inhibited cancer cell proliferation when loaded with drugs.

Conclusions:

A new, structure-preserving method for aldehyde group-functionalized polysaccharides was established.
The developed injectable hydrogel shows significant potential for advanced drug delivery systems.
Preserving the polysaccharide backbone's integrity is crucial for enhanced material properties and functionality.