Topography and Choroidal Thickness Measurement in Healthy Asian Indian Subjects using RTVue XR 100 Optical Coherence...

Area of Science:

• Ophthalmology
• Medical Imaging
• Anatomy

Background:

• Choroidal thickness is a key indicator of ocular health.
• Understanding its variations in different populations is crucial for diagnosing eye conditions.
• Optical coherence tomography (OCT) provides high-resolution imaging of the choroid.

Purpose of the Study:

• To establish a normative database of choroidal thickness and its topographic profile in healthy Asian Indian subjects.
• To investigate the correlation between choroidal thickness and factors like age, refractive error, and axial length.
• To utilize the RTVue XR 100 OCT device for precise choroidal measurements.

Main Methods:

• A cross-sectional study involving 150 healthy Asian Indian subjects (300 eyes).
• High-resolution imaging using RTVue XR 100 OCT with a line scan protocol.
• Measurement of subfoveal choroidal thickness and its profile at various points (nasal and temporal) up to 3000 μm from the fovea.

Main Results:

• Median subfoveal choroidal thickness was 235 μm.
• Choroidal thickness was greatest in the subfoveal region and decreased towards the periphery.
• Thicker choroid was observed temporally compared to nasally at all measured locations (P < 0.00001).
• Subfoveal choroidal thickness showed a negative correlation with age (P=0.03) and axial length (P=0.02), decreasing by 0.62 μm/year.

Conclusions:

• The study provides a normative topographic profile of choroidal thickness in healthy Asian Indian eyes.
• This data is valuable for clinical assessment and research using OCT.
• Choroidal thickness is influenced by age and axial length in this population.