Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Therapeutic Index

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

Classification of Illness

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...

Ethical Issues

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:

Methods of Documentation II: POMR

Methods of Documentation II: POMR

The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.

Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch

Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch

The history of therapeutic communication can be traced back to Florence Nightingale, who emphasized the importance of developing trusting relationships with patients. She taught that the presence of nurses with patients results in therapeutic healing.
Therapeutic communication is not the same as social interaction. Social interaction has no goal or purpose and consists of casual information sharing, whereas therapeutic communication has a plan or purpose for the conversation. Therapeutic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dietary Habits in Early Pregnancy in a Multi-Ethnic Population: Results from the PROMOTE Cohort Study.

Nutrients·2025

Same author

Association Between Intensity of Physical Activity in Pregnancy and Gestational Diabetes in a Multi-Ethnic Population: Results from the PROMOTE Cohort Study.

Nutrients·2025

Same author

Refining Methods of Experience-Based Co-Design for Application in Aphasia and Cognitive-Communication Disability.

American journal of speech-language pathology·2025

Same author

Improving maternal and PeRinatal Outcomes aMong wOmen with and without obEsity (PROMOTE): protocol for a prospective pregnancy cohort study.

BMJ open·2025

Same author

Implementing a remote self-screening programme for atrial fibrillation using digital health technology among community-dwellers aged 75 years and older: a qualitative evaluation.

BMJ open·2024

Same author

A Cross-Sectional Survey of Fixed-Dose Combination Antihypertensive Medicine Prescribing in Twenty-Four Countries, Including Qualitative Insights.

Global heart·2024

Same journal

Dual antihypertensive fixed-dose combinations approved for first-line use on the Pharmaceutical Benefits Scheme.

Australian prescriber·2026

Same journal

Capivasertib for locally advanced or metastatic breast cancer.

Australian prescriber·2026

Same journal

Diagnosis and management of irritable bowel syndrome.

Australian prescriber·2026

Same journal

Stopping antidepressants: when and how.

Australian prescriber·2026

Same journal

Emergency contraception: an overview.

Australian prescriber·2026

Same journal

Sodium valproate: balancing benefits and risks especially in people of childbearing potential.

Australian prescriber·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2025

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Published on: August 15, 2016

Therapeutic inertia.

Tim Usherwood^1,2,3

¹The University of Sydney.

Australian Prescriber

|March 6, 2024

Summary

This summary is machine-generated.

Therapeutic inertia, the failure to intensify treatment when goals aren't met, impacts chronic disease control. Addressing clinician and patient factors, alongside interventions like guidelines and monitoring, can improve care.

Keywords:

chronic disease diabetes mellitus guidelines hypertension prescribing quality use of medicines

More Related Videos

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

Related Experiment Videos

Last Updated: Jul 1, 2025

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Robotic Mirror Therapy System for Functional Recovery of Hemiplegic Arms

Published on: August 15, 2016

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb

Published on: September 23, 2018

Area of Science:

Clinical Medicine
Pharmacology
Health Services Research

Background:

Therapeutic inertia, or clinical inertia, is defined as the failure to initiate or intensify therapy when therapeutic goals are not achieved.
This inertia is linked to suboptimal control across various chronic conditions.
Understanding contributing factors is crucial for improving patient outcomes.

Purpose of the Study:

To define therapeutic inertia and its impact on chronic disease management.
To identify clinician and patient factors associated with therapeutic inertia.
To outline interventions aimed at reducing therapeutic inertia.

Main Methods:

Literature review and synthesis of existing definitions and contributing factors.
Analysis of clinician-related barriers (knowledge, uncertainty, safety concerns, time).
Examination of patient-related factors (demographics, comorbidities, proximity to target).

Main Results:

Therapeutic inertia is a significant barrier to optimal chronic disease control.
Clinician factors include knowledge gaps, uncertainty, safety concerns, and time constraints.
Patient factors include male sex, older age, comorbidities, and parameters near target.

Conclusions:

Therapeutic inertia contributes to undertreatment and poor disease control.
Interventions such as evidence-based guidelines, point-of-care tools, education, and patient prompting are effective.
Shared decision-making and monitoring can help overcome inertia and improve adherence.