Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.8K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

1.9K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.9K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innate Immunity of Framework Nucleic Acids.

Accounts of chemical research·2026
Same author

A multiple-encrypted DNA device for secure communication.

Science advances·2026
Same author

Direct impure water electrolysis at industrial scale.

Chemical Society reviews·2026
Same author

Bromide-Mediated Low-Energy Ru<sup>IV</sup>═O Pathway of Stable Water Oxidation.

Angewandte Chemie (International ed. in English)·2026
Same author

Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity.

Angewandte Chemie (International ed. in English)·2026
Same author

Trehalose-6-phosphate phosphatase-mediated trehalose metabolism shapes sorghum grain domestication for brewing adaptation.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2026
Same journal

Large-scale discovery and annotation of substructure patterns in mass spectrometry profiles.

Nature communications·2026
Same journal

Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression.

Nature communications·2026
Same journal

A human-specific microRNA controls the timing of excitatory synaptogenesis.

Nature communications·2026
Same journal

An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector.

Nature communications·2026
Same journal

Learning regularities in noise engages both neural predictive activity and representational changes.

Nature communications·2026
Same journal

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2025

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

155

An artificial protein modulator reprogramming neuronal protein functions.

Peihua Lin1,2, Bo Zhang1,3, Hongli Yang2

  • 1Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai, 200240, China.

Nature Communications
|March 6, 2024
PubMed
Summary
This summary is machine-generated.

Artificial protein modulators (APROMs) were engineered to reverse aberrant protein phosphorylation, a key process in diseases. These APROMs restore synaptic function in Parkinson's disease models by targeting hyperphosphorylated proteins.

More Related Videos

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.2K
Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
11:57

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

6.7K

Related Experiment Videos

Last Updated: Jul 1, 2025

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

155
Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.2K
Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
11:57

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

6.7K

Area of Science:

  • Biochemistry
  • Chemical Biology
  • Neuroscience

Background:

  • Reversible protein phosphorylation is crucial for cellular functions, regulated by protein phosphatases.
  • Dysregulation of phosphorylation leads to aberrant post-translational modifications (PTMs) and disease.
  • Artificial catalysts for direct protein modulation are underexplored.

Purpose of the Study:

  • To develop artificial protein modulators (APROMs) for reversing aberrant PTMs.
  • To enable precise control over protein function for therapeutic applications.
  • To investigate APROMs' efficacy in neurological disease models.

Main Methods:

  • Atomic-level engineering of heterogeneous catalysts with asymmetric centers.
  • Designing APROMs with structural and functional similarity to protein phosphatases.
  • Assessing APROMs' ability to hydrolyze phospho-substrates and reprogram protein function.

Main Results:

  • APROMs were developed with protein phosphatase-like characteristics.
  • APROMs effectively destabilize bridging μ3-hydroxide, activating catalytic centers.
  • APROMs catalytically reprogramed α-synuclein by hydrolyzing hyperphosphorylated forms, reinforcing synaptic function in Parkinson's disease models.

Conclusions:

  • APROMs offer a novel strategy for de novo PTMs and protein function reprogramming.
  • This approach holds promise for developing new therapies for diseases linked to aberrant phosphorylation.
  • Direct catalytic modulation of protein PTMs represents a significant advancement in chemical biology.