Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Quantifying and Rejecting Outliers: The Grubbs Test01:02

Quantifying and Rejecting Outliers: The Grubbs Test

1.6K
Sometimes, a data set can have a recorded numerical observation that greatly  deviates from the rest of the data. Assuming that the data is normally distributed, a statistical method called the Grubbs test can be used to determine whether the observation is truly an outlier.  To perform a two-tailed Grubbs test, first, calculate the absolute difference between the outlier and the mean. Then, calculate the ratio between this difference and the standard deviation of the sample. This...
1.6K
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data01:16

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

129
Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
129
Regression Analysis01:11

Regression Analysis

5.7K
Regression analysis is a statistical tool that describes a mathematical relationship between a dependent variable and one or more independent variables.
In regression analysis, a regression equation is determined based on the line of best fit– a line that best fits the data points plotted in a graph. This line is also called the regression line. The algebraic equation for the regression line is called the regression equation. It is represented as:
5.7K
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test01:09

Statistical Methods to Analyze Parametric Data: Student t-Test and Goodness-of-Fit Test

1.6K
In parametric statistics, two fundamental tests stand out for their utility and wide application: the Student's t-test and goodness-of-fit tests. These tests provide researchers with a robust method for drawing insights from data, testing hypotheses, and making informed decisions based on their findings.
The Student's t-test is a statistical test that examines if there is a statistically significant difference between the means of two groups. This test is instrumental when dealing with...
1.6K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

498
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
498

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fine-tuning and structured prompting strategies for question answering over full-text biomedical research articles.

PloS one·2026
Same author

Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population.

Research square·2026
Same author

Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases.

bioRxiv : the preprint server for biology·2026
Same author

CAR-iNKT cells for cancer therapy: a comprehensive review of engineering, mechanisms, and clinical progress.

Immunotherapy·2026
Same author

Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population.

medRxiv : the preprint server for health sciences·2026
Same author

Constrained Design of a Binary Instrument in a Partially Linear Model.

Observational studies·2026
Same journal

Poisoning the Genome: Targeted Backdoor Attacks on DNA Foundation Models.

ArXiv·2026
Same journal

Mechanistic mathematical model of the in vitro infection dynamics of Bunyamwera and Batai viruses including MOI-dependent shortening of the eclipse phase.

ArXiv·2026
Same journal

AI-Driven Lumped-Element Modeling of Human Respiratory System for Studying Voice Mechanics.

ArXiv·2026
Same journal

Beyond Algorithms: Conceptual Innovation in Medical Imaging AI.

ArXiv·2026
Same journal

Feynman Kac Reweighted Schrödinger Bridge Matching for Surface-Based Tau PET Harmonization.

ArXiv·2026
Same journal

Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3.

ArXiv·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2025

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
07:34

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

Published on: August 22, 2018

8.2K

Controlled Variable Selection from Summary Statistics Only? A Solution via GhostKnockoffs and Penalized Regression.

Zhaomeng Chen1, Zihuai He2,3, Benjamin B Chu4

  • 1Department of Statistics, Stanford University.

Arxiv
|March 11, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces new variable selection methods for analyzing summary statistics, improving accuracy in identifying influential variables while controlling false discoveries. The approach enhances performance in genetic studies, including Alzheimer's disease research.

Keywords:
Variable selectionfalse discovery rate (FDR)genome-wide association study (GWAS)knockoffspseudo-lassoreplicabilitysummary statistics

More Related Videos

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.3K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.5K

Related Experiment Videos

Last Updated: Jul 1, 2025

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
07:34

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients

Published on: August 22, 2018

8.2K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.3K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.5K

Area of Science:

  • Statistics
  • Data Science
  • Genomics

Background:

  • Identifying influential variables is crucial in statistics and data science.
  • Access to only summary statistics, like marginal correlations, is common due to privacy concerns, especially in genetic studies.
  • Controlling false discovery rate (FDR) is essential for reliable variable selection.

Approach:

  • Extends the GhostKnockoffs framework (He et al., 2022).
  • Develops novel variable selection methods utilizing penalized regression.
  • Achieves theoretical false discovery rate (FDR) control.

Key Points:

  • Methods demonstrated superior performance in extensive simulation studies compared to existing approaches.
  • Significant power improvement observed in genome-wide association studies (GWAS) for Alzheimer's disease.
  • The approach is suitable for scenarios with privacy constraints, using only summary statistics.

Conclusions:

  • The proposed penalized regression methods offer a powerful tool for variable selection with FDR control using summary statistics.
  • This work advances statistical methods for genetic association studies, particularly for complex diseases like Alzheimer's.
  • The methods provide a privacy-preserving alternative for analyzing sensitive data.