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Mouse Kidney Transplantation: Models of Allograft Rejection

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Published on: October 11, 2014

Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?

Katharina Kusejko^1,2, Dionysios Neofytos³, Christian van Delden³

¹Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.

Open Forum Infectious Diseases

|March 11, 2024

Summary

Infectious disease events were less frequent after kidney retransplantation (re-K-Tx) compared to first kidney transplantation (f-K-Tx). Specific infection sites and pathogen types also differed between re-K-Tx and f-K-Tx patients.

Keywords:

infections kidney retransplantation organ allocation

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Last Updated: Jul 1, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection

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Published on: October 11, 2014

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

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Published on: May 7, 2019

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Published on: April 12, 2021

Area of Science:

Nephrology
Infectious Diseases
Transplantation Immunology

Background:

Infectious diseases (IDs) are a major cause of morbidity and mortality post-solid organ transplantation.
Patients undergoing kidney retransplantation (re-K-Tx) are on prolonged immunosuppression, potentially increasing infection risk.
Comparing ID events in re-K-Tx versus first kidney transplantation (f-K-Tx) can clarify risks associated with extended immunosuppression.

Purpose of the Study:

To compare the incidence, types, and sites of infectious disease events after re-K-Tx and f-K-Tx within the same patient cohort.
To identify specific patterns of infections related to prolonged immunosuppressive therapy.

Main Methods:

Analysis of adult patients from the Swiss Transplant Cohort Study with records of both f-K-Tx and re-K-Tx.
Comparison of ID events occurring after f-K-Tx and re-K-Tx in the same individuals.
Recurrent time-to-event analyses were used to compare infection rates.

Main Results:

A total of 312 ID events were recorded in 52 out of 59 patients.
The rate of ID events was significantly lower after re-K-Tx (HR 0.70, P = .02).
Bacterial and fungal infections were more common after f-K-Tx, while viral infections were more frequent after re-K-Tx. Urinary and gastrointestinal infections predominated after f-K-Tx, whereas respiratory and surgical site infections were more common after re-K-Tx (P < .001).

Conclusions:

Infectious disease events occur less frequently following kidney retransplantation compared to first kidney transplantation.
The anatomical sites and types of infections differ significantly between f-K-Tx and re-K-Tx, highlighting distinct risks associated with prolonged immunosuppression.