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Small-molecule fluorogenic probes based on indole scaffold.

Pintu Ghosh1, Anirban Karak1, Ajit Kumar Mahapatra1

  • 1Molecular Sensor and Supramolecular Chemistry Laboratory, Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah-711103, West Bengal, India. akmahapatra@chem.iiests.ac.in.

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This summary is machine-generated.

This review details indole-based fluorescent and colorimetric chemosensors for detecting various analytes. It explores their design, recognition mechanisms, and applications in analytical chemistry.

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Area of Science:

  • Analytical Chemistry
  • Organic Chemistry
  • Materials Science

Background:

  • Indoles are versatile N-heterocyclic compounds found in natural products and utilized across diverse scientific fields.
  • The indole scaffold is increasingly employed in analytical chemistry for creating small-molecule fluorescent chemosensors.
  • These chemosensors are vital for molecular recognition and imaging applications.

Purpose of the Study:

  • To comprehensively review indole-based small-molecule fluorimetric and colorimetric chemosensors.
  • To discuss the detailed recognition mechanisms of these chemosensors.
  • To aid researchers in designing advanced fluorescent chemosensors.

Main Methods:

  • Review of literature on indole-based chemosensors.
  • Analysis of sensor design principles involving heteroatoms (N, O, S).
  • Discussion of analytical signal generation (fluorimetric and colorimetric).

Main Results:

  • Indole derivatives effectively detect cations, anions, and neutral species.
  • Heteroatoms in indole scaffolds facilitate analyte interaction and signal transduction.
  • Applications span biological, agricultural, and environmental sample analysis.

Conclusions:

  • Indole-based chemosensors offer versatile platforms for analyte detection.
  • Understanding recognition mechanisms is key to developing more efficient sensors.
  • This review provides a foundation for future advancements in chemosensor design.