Quantifying tics: Best practices and design considerations for video-based tic coding in research

Area of Science:

• Neurology
• Behavioral Science
• Clinical Research Methodology

Background:

• Tic disorders (TD), including Tourette Syndrome, involve involuntary movements and vocalizations causing significant lifelong impairment.
• Current tic measurement relies on subjective questionnaires, lacking objectivity.
• Video-based behavioral coding (VBBC) provides a more objective method for quantifying tics, gaining popularity due to ease of video acquisition.

Purpose of the Study:

• To establish standardized "best practices" for VBBC in tic disorder research.
• To address limitations in rigor and reproducibility caused by unstandardized VBBC methods.
• To guide researchers in implementing reliable and reproducible VBBC for tic disorder assessment.

Main Methods:

• The paper details a comprehensive approach to VBBC in TD research, refined over 15+ years.
• Key considerations include data acquisition protocols, coding implementation strategies, and interrater reliability (IRR) assessment.
• Guidelines cover methods reporting and ethical considerations for VBBC studies.

Main Results:

• The proposed "best practices" enhance the reliability and reproducibility of VBBC in TD research.
• Standardized methods ensure consistent and objective tic quantification.
• The framework facilitates more rigorous scientific investigation of tic disorders.

Conclusions:

• Implementing standardized VBBC "best practices" is crucial for advancing tic disorder research.
• This approach improves the objectivity and reliability of tic measurement.
• Adherence to these guidelines will enhance the quality and impact of VBBC studies in TD.