Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Bone Marrow Reserve to Metastatic Niche: How Neutrophil-Lineage Cells Shape Skeletal Colonization.

International journal of molecular sciences·2026
Same author

Nanoparticle Strategies for Bone Metastasis Immunotherapy: Targeting, Immune Reprogramming and Combination Therapy.

Pharmaceutics·2026
Same author

Decoding the Role of MDSCs in Bone Metastasis: Multicellular Interactions and Clinical Implications.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Osteocytes in the Metastatic Bone Niche: Mechanistic Pathways and Therapeutic Targets.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

The Neuro-Bone Axis in Metastatic Progression: Innervation, Neuro-Immune-Osteoclast Crosstalk, and Therapeutic Opportunities.

Biology·2026
Same author

Hematopoietic Niche Hijacking in Bone Metastases: Roles of Megakaryocytes, Erythroid Lineage Cells, and Perivascular Stromal Subsets.

Biomedicines·2026

Related Experiment Video

Updated: Jul 1, 2025

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K

Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective.

Basant Elaasser1, Nour Arakil1, Khalid S Mohammad1

  • 1Department of Anatomy, College of Medicine, Alfaisal University, Riyadh 1153, Saudi Arabia.

International Journal of Molecular Sciences
|March 13, 2024
PubMed
Summary

Advanced cancer often spreads to the bone, causing disabling complications. Understanding bone remodeling and metabolic changes is key to developing new treatments for bone metastases.

Keywords:
bone metastasesbone microenvironmentbone remodelingmetabolic reprogrammingtherapy

More Related Videos

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.4K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.7K

Related Experiment Videos

Last Updated: Jul 1, 2025

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.4K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.7K

Area of Science:

  • Oncology
  • Bone Biology
  • Metabolic Research

Background:

  • Bone metastases are a common and disabling complication of advanced cancers like prostate, breast, and lung cancer.
  • Currently, effective treatments for bone metastases are lacking.
  • The bone microenvironment, including osteoblasts and osteoclasts, plays a critical role in cancer progression.

Purpose of the Study:

  • To review the pathophysiology of bone metastases.
  • To explore the role of bone remodeling, metabolic reprogramming, and systemic factors in metastasis development.
  • To examine current and emerging therapeutic strategies for bone metastases.

Main Methods:

  • Literature review focusing on bone remodeling processes.
  • Analysis of metabolic reprogramming in cancer and bone cells.
  • Examination of systemic factors (hormones, cytokines) influencing bone metastasis.
  • Review of existing and novel therapeutic alternatives.

Main Results:

  • Cancer cells exploit the bone remodeling process, creating a self-perpetuating loop that enhances metastasis.
  • Metabolic reprogramming of cancer and bone microenvironment cells significantly impacts metastasis development.
  • Hormones and cytokines are critical systemic regulators of bone metastasis.

Conclusions:

  • A comprehensive understanding of bone remodeling and metabolic changes is crucial for developing effective treatments.
  • Targeting the bone microenvironment holds promise for treating bone metastases.
  • Further research into novel therapeutic strategies is essential for improving patient outcomes.