Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Correlation between ECG and Cardiac Cycle

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping global inequities in telemedicine implementation: An umbrella review of barriers and facilitators.

PloS one·2026

Same author

One echocardiographic or hemodynamic parameter improves mortality prediction by the ESC/ERS four-strata model: a flexible approach to follow-up risk stratification in pulmonary arterial hypertension.

European heart journal. Quality of care & clinical outcomes·2026

Same author

Stereoretentive Norrish-Yang Photocyclization Mediated by Hydrogen Bonding.

Journal of the American Chemical Society·2026

Same author

Tracing the pathogenic PLN p.(Arg14del) variant across the globe; more than just a local curiosity.

Journal of cardiovascular translational research·2026

Same author

Real-world Sotatercept Eligibility: Analysis from the FOCUS-PAH Registry.

Respiration; international review of thoracic diseases·2026

Same author

Cardiac mechanopathies: regional stress maldistribution as a primary determinant of myocardial disease.

Heart (British Cardiac Society)·2026

Search research articles

Related Experiment Video

Updated: Jul 1, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Endocardial repolarization dispersion in BrS: A novel automatic algorithm for mapping activation recovery interval.

Sara Latrofa¹, Valentina Hartwig², Lorenzo Bachi¹

¹Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.

Journal of Cardiovascular Electrophysiology

|March 13, 2024

Summary

Repolarization dispersion in the right ventricular outflow tract (RVOT) is increased in Brugada syndrome (BrS). This study shows endocardial activation recovery interval corrected (ARIc) mapping is feasible and correlates with other repolarization markers in BrS patients.

Keywords:

Brugada syndrome Tpeak‐Tend interval activation recovery interval electroanatomic substrate endocardial mapping repolarization dispersion

More Related Videos

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

High-resolution Optical Mapping of the Mouse Sino-atrial Node

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Related Experiment Videos

Last Updated: Jul 1, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

High-resolution Optical Mapping of the Mouse Sino-atrial Node

High-resolution Optical Mapping of the Mouse Sino-atrial Node

Published on: December 2, 2016

Area of Science:

Electrophysiology
Cardiology
Medical Imaging

Background:

Repolarization dispersion in the right ventricular outflow tract (RVOT) is implicated in Brugada syndrome (BrS) type-1 ECG phenotype.
Limited data exist on mapping repolarization dispersion in BrS, and the role of endocardial repolarization is poorly understood.

Purpose of the Study:

To assess endocardial repolarization patterns using automated activation recovery interval (ARI) calculation in BrS patients and controls.
To investigate the relationship between ARI, right ventricle activation time (RVAT), and T-wave peak-to-end interval (Tpe) in BrS patients.

Main Methods:

Endocardial high-density electroanatomical mapping (HDEAM) was performed on 39 BrS patients (24 overt type-1 [OType1], 15 latent type-1 [LType1]) and 4 controls.
LType1 patients received ajmaline infusion to unmask type-1 ECG.
Activation recovery interval corrected (ARIc) was calculated using the Bazett formula; RVAT was derived from activation maps.

Main Results:

OType1 and post-ajmaline LType1 patients exhibited significantly longer mean ARIc compared to controls.
Ajmaline administration significantly prolonged ARIc in LType1 patients.
In patients with type-1 ECG, ARIc showed positive correlations with RVAT and Tpe, particularly in OType1 subjects.

Conclusions:

ARIc mapping effectively demonstrates increased endocardial repolarization dispersion in the RVOT of BrS patients.
Endocardial ARIc is a feasible marker that positively correlates with RVAT and Tpe, especially in overt type-1 BrS.