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Related Experiment Video

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Altered functional-structural coupling may predict Parkinson's patient's depression.

Min Wang1, Changlian Tan1, Qin Shen1

  • 1Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.

Brain Structure & Function
|March 13, 2024
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Summary

Depression in Parkinson's disease (PD) is linked to altered functional-structural coupling in the brain. This study identifies potential imaging markers for depression in PD patients, showing promise for diagnosis.

Keywords:
Cortical thicknessDepressionFunction-structure couplingFunctional magnetic resonance imagingParkinson’s diseaseSurface-based ReHo

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Imaging

Background:

  • Depression is a common non-motor symptom in Parkinson's disease (PD).
  • The neurobiological underpinnings of depression in PD remain incompletely understood.
  • Identifying reliable biomarkers for depression in PD is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the neurobiological basis of depression in Parkinson's disease (PD).
  • To identify potential neuroimaging markers for depression in PD patients.
  • To explore the relationship between functional and structural brain changes in depressed PD patients.

Main Methods:

  • Recruited 43 normal controls (NC), 46 depressed PD patients (DPD), and 56 non-depressed PD patients (NDPD).
  • Utilized 3.0 T MRI (T2-weighted, T2Flair, resting-state) to assess surface-based Regional Homogeneity (2DReHo) and cortical thickness.
  • Calculated functional-structural coupling index and performed statistical comparisons, logistic regression, and ROC analysis.

Main Results:

  • DPD patients showed significantly lower whole-brain functional-structural coupling compared to NDPD patients and NC.
  • Abnormal coupling was identified in the left inferior parietal lobule and right visual cortices in DPD patients.
  • A combination of cortical functional-structural coupling, ReHo, and thickness achieved 65% sensitivity and 77.7% specificity for diagnosing depression in PD.

Conclusions:

  • Altered functional-structural coupling represents a potential neuroimaging biomarker for depression in Parkinson's disease.
  • These findings offer insights into the neurobiological mechanisms of depression in PD.
  • The identified markers may aid in the classification and diagnosis of depression within the PD population.