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A Golgi Apparatus-Targeted Photothermal Agent with Protein Anchoring for Enhanced Cancer Photothermal Therapy

Mingwan Shi1, Zhongliang Fu1, Wei Pan1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Jinan, 250014, P. R. China.

Advanced Healthcare Materials
|March 14, 2024
PubMed

Insights

This study introduces a novel Golgi apparatus-targeted photothermal agent for cancer therapy. This agent precisely destroys tumor cells via localized heat, enhancing photothermal therapy effectiveness and reducing side effects.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Nanotechnology

Background:

  • The Golgi apparatus (GA) is crucial for protein transport from the endoplasmic reticulum.
  • Targeting the GA for protein disruption offers a potential cancer therapy strategy.
  • Photothermal therapy uses localized heat to destroy cells.

Purpose of the Study:

  • To develop a Golgi apparatus-targeted photothermal agent for enhanced cancer therapy.
  • To investigate the agent's ability to anchor to and disrupt GA proteins via localized heat.
  • To evaluate the in vivo efficacy and safety of this novel therapeutic approach.

Main Methods:

  • Modification of a near-infrared molecular dye with maleimide derivative and benzene sulfonamide to create the photothermal agent.
  • Utilizing protein anchoring for active targeting and covalent binding to GA sulfhydryl proteins.
  • Employing laser irradiation to induce localized hyperthermia and subsequent apoptosis.

Main Results:

  • The photothermal agent successfully targeted and anchored to the Golgi apparatus.
  • Localized heat disrupted sulfhydryl proteins within the GA, causing dysfunction.
  • In vivo studies showed precise tumor treatment and significantly reduced side effects.

Conclusions:

  • The developed Golgi apparatus-targeted photothermal agent is effective for cancer therapy.
  • Protein anchoring enhances agent retention and therapeutic efficacy.
  • This approach offers a promising strategy for precise tumor destruction with minimized off-target effects.
Keywords:
Golgi apparatus targetingcancer therapymolecular photothermal agentphotothermal therapyprotein anchoring

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