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Related Concept Videos

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Related Experiment Video

Updated: Jun 30, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

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Thyroid Cancer With Cutaneous Metastases.

Bao Y Sciscent1, Hanel W Eberly1, Neerav Goyal1

  • 1Department of Otolaryngology-Head and Neck Surgery, Penn State Milton S. Hershey Medical Center and Penn State College of Medicine, Hershey, PA, USA.

Ear, Nose, & Throat Journal
|March 15, 2024
PubMed
Summary

Cutaneous metastases from thyroid carcinoma are rare but indicate a poor prognosis. This review highlights demographic, clinical, and survival data for these challenging cases.

Keywords:
cutaneous metastasespapillary thyroid cancerskin metastasesthyroid cancerthyroid carcinoma

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Cutaneous metastases from thyroid carcinoma are uncommon and associated with poor prognosis.
  • Existing data are limited to case reports, with unclear metastatic mechanisms.
  • This study aims to consolidate demographic, clinical, and histological findings.

Purpose of the Study:

  • To review and report on the demographic, clinical, and histological characteristics of thyroid carcinoma with cutaneous metastases.
  • To analyze the incidence, common histotypes, locations, and survival outcomes.

Main Methods:

  • A comprehensive literature review was performed using Medline/PubMed, Cochrane, and Scopus databases up to May 2023.
  • Data extracted included patient demographics, thyroid carcinoma histotype, metastasis location, time to metastasis, and overall survival.
  • 136 cases of thyroid carcinoma with cutaneous metastases were identified.

Main Results:

  • Papillary (47.79%), follicular (30.15%), and medullary (11.03%) were the most common histotypes.
  • The average age at diagnosis of cutaneous metastases was 63.13 years, with a mean interval of 48.27 months from primary diagnosis.
  • The scalp was the most frequent metastasis site (n=48); overall survival averaged 13.07 months for available cases.

Conclusions:

  • Cutaneous metastasis of thyroid carcinoma, though rare, signifies a poor prognosis and requires a high index of suspicion.
  • This review provides an updated overview of these metastases, emphasizing their clinical implications.
  • Further research into the mechanisms and management of thyroid carcinoma cutaneous metastases is warranted.