Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
What is Cancer?02:12

What is Cancer?

10.7K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
10.7K
Cancer Therapies02:49

Cancer Therapies

7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Managing, Analyzing and Sharing Research Data with Gen3 Data Commons.

Scientific data·2026
Same author

Laying the Foundation for Clinically Actionable Genomic Subtyping in Diffuse Large B-cell Lymphoma.

Blood cancer discovery·2026
Same author

The importance of studying sex and gender in cancer research: Why and how.

Cancer·2026
Same author

In search of truth: evaluating concordance of AI-based anatomy segmentation models.

Journal of medical imaging (Bellingham, Wash.)·2026
Same author

Building Pediatric Cancer Cohorts and Accessing Data Using Childhood Cancer Data Initiative Tools.

JCO clinical cancer informatics·2025
Same author

GDC Cohort Copilot: an AI copilot for curating cohorts from the genomic data commons.

Bioinformatics advances·2025

Related Experiment Video

Updated: Jun 30, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K

NCI Cancer Research Data Commons: Resources to Share Key Cancer Data.

Zhining Wang1, Tanja M Davidsen1, Gina R Kuffel2

  • 1Center for Biomedical Informatics and Information Technology, NCI, Rockville, Maryland.

Cancer Research
|March 15, 2024
PubMed
Summary
This summary is machine-generated.

The National Cancer Institute

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.7K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

Related Experiment Videos

Last Updated: Jun 30, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.7K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.6K

Area of Science:

  • Oncology
  • Bioinformatics
  • Data Science

Background:

  • The National Cancer Institute (NCI) established the Cancer Research Data Commons (CRDC) in 2014.
  • The CRDC is an ecosystem designed to house diverse datasets, including genomic, proteomic, imaging, and clinical data.
  • The primary goal is to support cancer research and facilitate data sharing for NCI-funded studies.

Purpose of the Study:

  • To review the various data commons within the CRDC ecosystem.
  • To describe their unique and shared features, accomplishments, and challenges.
  • To discuss the implementation of Findable, Accessible, Interoperable, Reusable (FAIR) principles and data sharing promotion in alignment with the NIH Data Management and Sharing Policy.

Main Methods:

  • Review of existing NCI data commons: Genomic Data Commons (GDC), Proteomic Data Commons (PDC), Integrated Canine Data Commons (ICDC), Cancer Data Service (CDS), Imaging Data Commons (IDC), and Clinical and Translational Data Commons (CTDC).
  • Analysis of unique and shared features, accomplishments, and challenges of each data commons.
  • Assessment of FAIR principles implementation and data sharing strategies.

Main Results:

  • Detailed descriptions of six NCI data commons are provided.
  • The review highlights both the distinct capabilities and commonalities across these platforms.
  • Accomplishments and challenges encountered in managing and sharing these diverse datasets are discussed.

Conclusions:

  • The CRDC data commons provide a robust infrastructure for cancer research data.
  • These commons are actively implementing FAIR principles to enhance data discoverability and usability.
  • The CRDC supports the NIH Data Management and Sharing Policy, promoting broader access to NCI-funded research data.