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Advances in 3D Bioprinted Cardiac Tissue Using Stem Cell-Derived Cardiomyocytes.
Jacqueline M Bliley1, Maria A Stang1, Anne Behre1
1Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Stem Cells Translational Medicine
|March 19, 2024
Summary
Cardiac tissue engineering aims to regenerate heart muscle using stem cell-derived cardiomyocytes and 3D bioprinting. This review covers progress, design criteria, and challenges for creating functional cardiac tissues.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Cardiovascular Research
Background:
- Cardiac tissue engineering seeks to repair or replace damaged heart muscle.
- Significant advances in stem cell technologies are needed to produce billions of cardiomyocytes.
- Sophisticated biofabrication methods, including 3D bioprinting, are crucial for achieving functional cardiac tissue.
Purpose of the Study:
- To review recent progress in 3D bioprinting of cardiac tissue.
- To discuss key design criteria for engineering aligned cardiac tissues.
- To identify ongoing challenges in cardiac tissue engineering.
Main Methods:
- Review of current literature on 3D bioprinting of cardiac tissue.
- Analysis of pluripotent stem cell-derived cardiomyocytes in tissue engineering.
- Examination of design principles for achieving contractile cardiac constructs.
Main Results:
- Recent progress in using stem cell-derived cardiomyocytes for cardiac tissue fabrication.
- Identification of critical design criteria for creating aligned cardiac tissues.
- Summary of current challenges hindering clinical translation.
Conclusions:
- 3D bioprinting holds promise for cardiac repair.
- Further research is needed to overcome challenges in cell differentiation and tissue maturation.
- Engineering aligned cardiac tissues is essential for functional recovery.
