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Updated: Jun 30, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
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Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and

Guang-Yuan Wang1,2, Dong-Xiao Yan3, Rui-Xue Rong3

  • 1College of Chemistry and Materials Science, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, Hebei Research Center of the Basic Discipline of Synthetic Chemistry, Hebei University, Baoding 071002, P. R. China.

Journal of Medicinal Chemistry
|March 20, 2024
PubMed
Summary

Self-assembling drug conjugates, LP-4DNJ-6C, effectively inhibit alpha-glucosidases in the small intestine. This study demonstrates a viable strategy for developing self-assembled multivalent hypoglycemic drugs.

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