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Related Concept Videos

Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Signs of Puberty01:27

Signs of Puberty

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Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Hormonal Regulation01:40

Hormonal Regulation

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Related Experiment Video

Updated: Jun 30, 2025

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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[Weight gain during menopause: physiology and practical implications].

Jorge César Correia1, Maria Mavromati2, Zoltan Pataky1

  • 1Unité d'éducation thérapeutique du patient, Centre collaborateur OMS, Service d'endocrinologie, diabétologie, nutrition et éducation thérapeutique du patient, Hôpitaux universitaires de Genève, 1211 Genève 14.

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|March 20, 2024
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Summary
This summary is machine-generated.

Hormonal shifts during menopause influence body composition, leading to fat accumulation and lean mass loss. While the exact contribution to weight gain is debated, personalized support is crucial for managing associated health risks.

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Area of Science:

  • Reproductive endocrinology
  • Metabolic health
  • Body composition analysis

Context:

  • Menopausal transition involves significant hormonal fluctuations, shifting from estrogen dominance to increased androgen levels.
  • This hormonal shift is linked to alterations in body composition, including increased adiposity and decreased muscle mass.

Purpose:

  • To explore the role of sex hormone fluctuations during the menopausal transition in weight regulation.
  • To investigate the contribution of body composition changes to menopausal weight gain.

Summary:

  • The menopausal transition is characterized by a shift in sex hormone balance, favoring an androgenic state.
  • This hormonal change is associated with fat accumulation and loss of lean mass, though its direct link to overall weight gain requires further investigation.
  • Physiological and psychosocial factors also play a role in weight management during this life stage.

Impact:

  • Highlights the complex interplay of hormones, body composition, and weight during menopause.
  • Emphasizes the need for individualized strategies to mitigate weight gain and related health issues.
  • Informs clinical practice and patient counseling regarding menopausal health and weight management.