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Metastatic Maxillary Gingival Angiosarcoma with Aggressive Growth: A Case Report
Yasutaka Hoshimoto1, Takayuki Aoki, Mebae Ichikawa
1Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. h.yasu3960@gmail.com.
The Tokai Journal of Experimental and Clinical Medicine
|March 20, 2024
Summary
This case report details a rare instance of metastatic epithelioid angiosarcoma presenting in the gingiva, originating from a primary mediastinal tumor. Early detection of oral metastases is crucial for identifying systemic malignancy.
Area of Science:
- Oncology
- Pathology
- Oral Surgery
Background:
- Angiosarcoma is a rare, aggressive vascular endothelial tumor.
- It accounts for 2% of soft tissue sarcomas, with oral cavity primary tumors being exceptionally rare (1%).
Observation:
- An 83-year-old male presented with a gingival mass, diagnosed histopathologically as epithelioid angiosarcoma.
- Imaging revealed widespread metastases including mediastinum, lungs, liver, and skin.
Findings:
- The oral lesion was determined to be a metastasis from an undiagnosed primary mediastinal angiosarcoma.
- The patient had a poor prognosis due to widespread metastatic disease.
Implications:
- Oral metastatic lesions can be the first sign of systemic malignancy.
- Oral and maxillofacial surgeons require heightened awareness for diagnosing metastatic angiosarcoma.

