Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform.

Analytical chemistry·2026

Same author

Nature Meets Science: The Role of Food-Grade Oils and Green Excipients in Pharmaceutical Nanoemulsion Formulation.

Materials (Basel, Switzerland)·2026

Same author

Lipid self-assembling nanoparticles as a novel platform for mRNA-based vaccination.

Molecular therapy. Nucleic acids·2026

Same author

Ultrasound-Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units.

Advanced healthcare materials·2025

Same author

Special issue: Phospholipids as functional ingredients in pharmaceutical formulations: Current advances and perspectives.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025

Same author

Development and evaluation of gluconic acid-targeted liposomal doxorubicin for enhanced anti-tumor activity in colon cancer.

Journal of pharmaceutical sciences·2025

Search research articles

Related Experiment Video

Updated: May 13, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies.

Valeria Nele¹, Virginia Campani¹, Seyedeh Alia Moosavian¹

¹Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 49 80131 Naples, Italy.

Advanced Drug Delivery Reviews

|March 21, 2024

Summary

This summary is machine-generated.

Lipid nanovectors are key for RNA therapeutics delivery. This review explores their assembly mechanisms and architectures for targeted RNA delivery, crucial for treating various diseases.

Keywords:

Core–shell nanoparticles Driven-assembling Lipid nanoparticles Lipid self-assembling Nanomedicine RNA delivery

More Related Videos

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Published on: August 23, 2024

Related Experiment Videos

Last Updated: May 13, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Published on: August 23, 2024

Area of Science:

Biotechnology
Nanomedicine
Drug Delivery Systems

Background:

Lipid nanovectors are the leading non-viral choice for RNA therapeutics.
Approved lipid nanoparticle products highlight their therapeutic potential.
Targeted delivery requires understanding disease pathways and tailoring nanovectors.

Purpose of the Study:

To review significant lipid nanovectors for RNA delivery.
To analyze nanovector potential based on assembly mechanisms and particle architecture.

Main Methods:

Literature review of lipid nanovector assembly and architecture.
Analysis of nanovector strategies for RNA loading and delivery.

Main Results:

Lipid nanovector morphology arises from self-assembly of lipid components.
Various methods can control nanoparticle organization.
Pre-formed nanoparticles can complex with RNA, inducing self-assembly.

Conclusions:

Understanding lipid nanovector assembly is crucial for optimizing RNA therapeutics.
Tailoring nanovector architecture to specific pathologies enhances delivery efficiency.