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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Related Experiment Video

Updated: Jun 30, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Myocardial fibrosis in right heart dysfunction.

Lucia Agoston-Coldea1, Andra Negru1

  • 1Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Advances in Clinical Chemistry
|March 21, 2024
PubMed
Summary

Cardiac fibrosis, a cause of right heart dysfunction, can be detected and monitored using circulating biomarkers. This review explores protein and miRNA markers for understanding pathophysiology and developing therapeutics to reverse cardiac fibrosis.

Keywords:
Cardiac fibroblastsCirculating miRsFibrillar collagensInflammatory signalsMyocardial fibrosisRight heart dysfunctionRight ventricularTGF-β signaling

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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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Area of Science:

  • Cardiology
  • Biomarkers
  • Fibrosis Research

Background:

  • Cardiac fibrosis contributes to right heart dysfunction, leading to significant morbidity and mortality.
  • Fibrosis is driven by cellular and humoral stimuli, involving various immune cells and leading to extracellular matrix modification.
  • Current detection relies on advanced imaging, but circulating biomarkers offer a cost-effective alternative.

Conclusions:

  • Circulating biomarkers offer a promising, accessible approach for managing cardiac fibrosis.
  • Understanding biomarker roles is crucial for developing targeted antifibrotic therapies.
  • Biomarkers can facilitate early detection and monitoring, potentially reversing cardiac fibrosis and improving patient outcomes.