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Updated: Jun 30, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Myocardial fibrosis in right heart dysfunction

Lucia Agoston-Coldea1, Andra Negru1

  • 1Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Advances in Clinical Chemistry
|March 21, 2024
PubMed

Insights

Cardiac fibrosis, a cause of right heart dysfunction, can be detected and monitored using circulating biomarkers. This review explores protein and miRNA markers for understanding pathophysiology and developing therapeutics to reverse cardiac fibrosis.

Area of Science:

  • Cardiology
  • Biomarkers
  • Fibrosis Research

Background:

  • Cardiac fibrosis contributes to right heart dysfunction, leading to significant morbidity and mortality.
  • Fibrosis is driven by cellular and humoral stimuli, involving various immune cells and leading to extracellular matrix modification.
  • Current detection relies on advanced imaging, but circulating biomarkers offer a cost-effective alternative.

Conclusions:

  • Circulating biomarkers offer a promising, accessible approach for managing cardiac fibrosis.
  • Understanding biomarker roles is crucial for developing targeted antifibrotic therapies.
  • Biomarkers can facilitate early detection and monitoring, potentially reversing cardiac fibrosis and improving patient outcomes.

Keywords:
Cardiac fibroblastsCirculating miRsFibrillar collagensInflammatory signalsMyocardial fibrosisRight heart dysfunctionRight ventricularTGF-β signaling

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