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Crosstalk between ubiquitin ligases and ncRNAs drives cardiovascular disease progression

Jia-Rui You1,2, Zeng-Jin Wen1,2, Jia-Wei Tian3

  • 1Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.

Frontiers in Immunology
|March 22, 2024
PubMed

Insights

The ubiquitin-proteasome system (UPS) and noncoding RNAs (ncRNAs) interact to influence cardiovascular diseases (CVDs). Understanding this crosstalk offers potential new therapeutic strategies for heart conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are leading causes of global mortality.
  • The ubiquitin-proteasome system (UPS) is vital for protein homeostasis.
  • Noncoding RNAs (ncRNAs) are key epigenetic regulators in cellular processes.

Purpose of the Study:

  • To review the intricate relationship between the UPS and ncRNAs in CVDs.
  • To highlight the role of their crosstalk in various cardiovascular pathologies.
  • To explore potential therapeutic applications targeting this interaction.

Main Methods:

  • Literature review and synthesis of current research.
  • Analysis of the molecular mechanisms linking UPS and ncRNAs in CVDs.
  • Discussion of pathological conditions including myocardial infarction, heart failure, and atherosclerosis.

Main Results:

  • The UPS and ncRNAs exhibit complex crosstalk influencing protein stability and cellular function.
  • This interaction is implicated in the pathogenesis of diverse CVDs.
  • Dysregulation of UPS-ncRNA pathways contributes to cardiovascular disease progression.

Conclusions:

  • Targeting the interplay between the UPS and ncRNAs presents a promising therapeutic avenue.
  • RNA interference and ncRNA modulators offer potential strategies for CVD treatment.
  • Further research into UPS-ncRNA interactions could revolutionize cardiovascular medicine.

Keywords:
UPScircRNAdeubiquitinationlncRNAmiRNAubiquitination

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