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Updated: Jun 30, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Fluorogenic polymethine dyes by intramolecular cyclization

Annabell Martin1, Pablo Rivera-Fuentes2

  • 1Department of Chemistry, University of Zurich, Zurich, Switzerland; École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Lausanne, Switzerland.

Current Opinion in Chemical Biology
|March 23, 2024
PubMed
Summary

Researchers developed new fluorogenic polymethine dyes for clearer live-cell imaging. These advanced dyes overcome limitations of previous versions, improving intracellular visualization in biological studies.

Keywords:
CarbocyaninesFluorogenicityIntramolecular cyclizationsLive-cell fluorescence nanoscopyPolymethine dyesSelf-labeling protein tagsSmall-molecule ligandsTurn-on probes

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