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Erbium(III) complexes with fluoroquinolones: Structure and biological properties
Eleni Arnaouti1, Christina Georgiadou2, Antonios G Hatizdimitriou1
1Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Journal of Inorganic Biochemistry
|March 24, 2024
Summary
New erbium(III) complexes with fluoroquinolones show enhanced antibacterial activity and bind tightly to DNA and serum albumin. These findings suggest potential therapeutic applications for these novel metal-organic compounds.
Area of Science:
- Coordination Chemistry
- Medicinal Chemistry
- Biochemistry
Background:
- Fluoroquinolones are a class of synthetic antibiotics.
- Erbium(III) complexes are being explored for various applications.
- Combining metal ions with antibiotics can alter their properties.
Purpose of the Study:
- To synthesize and characterize novel erbium(III) complexes with fluoroquinolone ligands.
- To evaluate the antibacterial activity of these complexes.
- To investigate the interaction of the complexes with DNA and serum albumin.
Main Methods:
- Synthesis and characterization using physicochemical and spectroscopic techniques, including single-crystal X-ray crystallography.
- Antibacterial activity testing against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Xanthomonas campestris.
- DNA interaction studies using UV-vis spectroscopy, DNA-viscosity measurements, and ethidium bromide displacement assays.
- Serum albumin binding studies using fluorescence emission spectroscopy.
Main Results:
- Four novel erbium(III)-fluoroquinolone complexes were successfully synthesized and characterized.
- The complexes exhibited enhanced antibacterial activity compared to the free fluoroquinolones.
- DNA interaction studies indicated intercalation as the primary binding mode.
- High affinity and tight, reversible binding to bovine and human serum albumin were observed.
Conclusions:
- Erbium(III) complexation enhances the antibacterial efficacy of fluoroquinolones.
- The complexes interact with DNA via intercalation and bind strongly to serum albumin.
- These findings highlight the potential of these erbium(III) complexes as therapeutic agents.
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