Related Experiment Video
Updated: May 3, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
Atypical Lyme Disease Rash: A Case Report
Selena Khanna1, Lynne J Goebel1
1Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, USA.
Lyme disease (LD) can present with unusual rashes beyond the typical bullseye. Recognizing these atypical presentations is vital for early diagnosis and treatment of this tick-borne illness.
Area of Science:
- Infectious Diseases
- Dermatology
- Public Health
Background:
- Lyme disease (LD) is a significant tick-borne illness in the United States, primarily caused by *Borrelia burgdorferi*.
- The classic erythema migrans (EM) rash is well-recognized, but LD manifests with diverse clinical presentations.
- Awareness of varied LD symptoms is crucial for timely medical intervention.
Observation:
- This report details a case of LD in a 69-year-old female.
- The patient presented with an atypical rash characterized by purplish discoloration.
- This rash lacked the typical outer ring or central clearing often associated with EM.
Findings:
- The case highlights that Lyme disease can manifest with non-classical skin findings.
- Atypical erythema migrans presentations may occur, challenging initial diagnosis.
- Prompt recognition of varied LD rash appearances is essential.
Implications:
- Healthcare providers must consider LD even in the absence of typical EM rash.
- Maintaining a high index of suspicion for LD is critical in endemic areas.
- Educating clinicians on diverse LD presentations can improve patient outcomes and public health.
More Related Videos
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Myocarditis II: Clinical Features and Diagnostic Tests
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Atypical Pneumonia
Encephalitis l: Introduction

