Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Same author

The Sex of Donor and Recipients in Solid Organ Transplantation: An in Depth Analysis Across the Council of Europe Member States.

Transplant international : official journal of the European Society for Organ Transplantation·2026

Same author

Breaking Barriers: Proof of Concept for Selective Coronary Endothelial Decellularization in Whole Porcine Hearts for Xenotransplantation.

Xenotransplantation·2026

Same author

Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Same author

Autoantibody Profiling in Cardiomyopathies: Toward Immune-Guided Risk Stratification and Therapy.

Journal of clinical medicine·2026

Same author

From transplant rejection to coronary no-reflow: an immune-ischemic framework for antibody-mediated microvascular dysfunction.

American journal of physiology. Heart and circulatory physiology·2026

Same journal

Introduction to pediatric solid organ transplantation - not just little adults!

Current opinion in organ transplantation·2026

Same journal

Editorial introduction.

Current opinion in organ transplantation·2026

Same journal

Precision medicine guided development of new immunosuppression strategies in solid organ transplantation.

Current opinion in organ transplantation·2026

Same journal

Intestinal transplantation for tumors.

Current opinion in organ transplantation·2026

Same journal

Current state of medical rehabilitation for adult short bowel syndrome patients with intestinal failure.

Current opinion in organ transplantation·2026

Same journal

Update on costimulatory blockade in transplantation: a review of recent literature.

Current opinion in organ transplantation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 29, 2025

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Current challenges in xenotransplantation.

Marta Vadori¹, Emanuele Cozzi^1,2

¹Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua.

Current Opinion in Organ Transplantation

|March 26, 2024

Summary

This summary is machine-generated.

Recent advances in xenotransplantation, using gene-edited pigs, have enabled longer survival in preclinical models and initial human compassionate use cases. Challenges in immunology, physiology, and biosafety remain for broader clinical application.

More Related Videos

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Related Experiment Videos

Last Updated: Jun 29, 2025

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Area of Science:

Xenotransplantation research
Organ transplantation
Genetic engineering

Background:

Xenotransplantation science has seen significant advancements in preclinical and clinical research.
Overcoming obstacles is crucial for the successful translation of xenotransplantation.

Purpose of the Study:

To review the latest progress in knowledge and methodologies for clinical xenotransplantation.
To identify and address potential obstacles in xenotransplantation.

Main Methods:

Utilizing genetically engineered pigs for xenografts.
Implementing careful donor and recipient selection.
Employing appropriate immunosuppressive strategies.

Main Results:

Extended survival beyond two years in primate recipients of xenografts.
Successful xenotransplantation in human decedents.
Compassionate use of genetically modified pig hearts in two human recipients.

Conclusions:

Preliminary results are encouraging for clinical xenotransplantation.
Immunologic, physiologic, and biosafety challenges require further investigation.
Recent progress facilitates initial compassionate use and broader future applications.