Cutaneous Angiosarcoma Subtypes: A Quantitative Systematic Review of Demographics, Treatments, and Outcomes Within...

Area of Science:

• Oncology
• Dermatology
• Vascular Biology

Background:

• Cutaneous angiosarcoma (cAS) is a rare and aggressive vascular malignancy.
• Limited data exists on cAS demographics, management, and survival outcomes due to its rarity.

Purpose of the Study:

• To systematically compile patient-level data on cAS.
• To analyze demographics, management strategies, and survival outcomes.
• To identify prognostic indicators for cAS.

Main Methods:

• Conducted systematic literature searches across major databases (EBSCOhost, MEDLINE, EMBASE, Cochrane Library).
• Compiled data from 1,500 patient-level cases of cAS.
• Followed PRISMA guidelines for systematic reviews.

Main Results:

• cAS most frequently affects elderly men, often on the scalp.
• Metastasis occurred in 36.3% of cases, with a 5-year survival rate of 31.6%.
• Radiation-associated cAS had better survival (48.8%) than Stewart-Treves subtype (21.6%).
• Multivariate analysis identified gender, age, subtype, treatment, and metastasis as significant prognostic factors (p < .05).

Conclusions:

• This comprehensive analysis provides valuable insights into cAS.
• The findings can serve as a clinical resource for managing cutaneous angiosarcoma.
• Understanding prognostic indicators is crucial for improving patient outcomes.