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Published on: June 7, 2015
Beyond Traditional Medicine: EVs-Loaded Hydrogels as a Game Changer in Disease Therapeutics
Shutong Du1, Xiaohu Zhou1, Bo Zheng1
1Institute for Cell Analysis, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Abstract:
Extracellular vesicles (EVs), especially exosomes, have shown great therapeutic potential in the treatment of diseases, as they can target cells or tissues. However, the therapeutic effect of EVs is limited due to the susceptibility of EVs to immune system clearance during transport in vivo. Hydrogels have become an ideal delivery platform for EVs due to their good biocompatibility and porous structure. This article reviews the preparation and application of EVs-loaded hydrogels as a cell-free therapy strategy in the treatment of diseases. The article also discusses the challenges and future outlook of EVs-loaded hydrogels.
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