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Development of a Sprayable Hydrogel-Based Wound Dressing: An In Vitro Model
Mine Altunbek1, Mert Gezek1,2, Maria Eduarda Torres Gouveia1
1Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA.
Gels (Basel, Switzerland)
|March 27, 2024
Summary
This study presents a novel sprayable hydrogel wound dressing made from hyaluronic acid and gelatin. The dressing offers self-oxygenation and antibacterial properties, enhancing wound healing potential.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Technologies
Background:
- Hydrogel dressings offer multifunctional wound healing benefits including antibacterial and anti-inflammatory properties.
- Sprayable application is crucial for rapid and effective wound coverage.
- Naturally derived polymers like hyaluronic acid and gelatin are promising for wound dressing development.
Purpose of the Study:
- To develop a sprayable hydrogel wound dressing using hyaluronic acid and gelatin.
- To incorporate self-oxygenating and antibacterial functionalities into the hydrogel.
- To evaluate the efficacy of the developed dressing for wound healing applications.
Main Methods:
- Hyaluronic acid and gelatin were modified with methacrylate groups (HAMA and GelMA) for photocrosslinking.
- Sprayability was optimized by varying GelMA concentration (5-15% w/v) with 1% HAMA.
- Calcium peroxide was incorporated (0-12 mg/mL) for oxygen release and antibacterial effects.
Main Results:
- The composite hydrogels demonstrated sprayability and sustained oxygen release for up to two weeks.
- Released oxygen mitigated hypoxia-induced metabolic stress and cell death in fibroblasts.
- Calcium peroxide incorporation provided effective antibacterial properties to the hydrogel dressing.
Conclusions:
- The developed sprayable hydrogel dressing exhibits potential for advanced wound healing.
- Its conformable application and integrated functionalities offer significant advantages.
- The self-oxygenating and antibacterial properties contribute to improved wound therapeutic outcomes.
