Related Experiment Video
Updated: Jun 29, 2025
08:53
Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
Published on: December 4, 2020
6.0K
Urinary bladder involvement in IgG4-related disease: A case-based review
Parag Vijayvergia1, Sayan Mukherjee1, Lily Singh1
1Department of Clinical Immunology and Rheumatology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Modern Rheumatology Case Reports
|March 27, 2024
Summary
Immunoglobulin G4-related disease (IgG4-RD) rarely affects the urinary bladder. This case highlights IgG4-RD mimicking bladder cancer, emphasizing early diagnosis and treatment to prevent damage.
Area of Science:
- Immunology
- Oncology
- Urology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a rare fibroinflammatory condition.
- While IgG4-RD commonly affects organs like the pancreas and liver, urinary bladder involvement is seldom reported.
- This disease can present as tumefactive lesions mimicking malignancies.
Purpose of the Study:
- To report a rare case of IgG4-RD involving the urinary bladder.
- To discuss the diagnostic challenges when IgG4-RD mimics bladder carcinoma.
- To review the literature on IgG4-RD presenting as a urinary bladder mass.
Main Methods:
- A case study of a 39-year-old male with urinary symptoms.
- Diagnostic imaging included ultrasound and contrast-enhanced computed tomography (CT).
- Biopsies guided by CT and ultrasound confirmed the diagnosis of IgG4-RD.
Main Results:
- Imaging revealed a bladder mass suspicious for malignancy with perivesical changes and a concurrent perigastric lesion.
- Histopathological examination confirmed IgG4-RD.
- The patient responded well to glucocorticoid therapy, with significant reduction in bladder mass size after one year.
Conclusions:
- IgG4-RD should be considered in the differential diagnosis of urinary bladder masses.
- Prompt diagnosis and treatment are crucial to minimize organ damage and surgical intervention.
- Early recognition of IgG4-RD can lead to favorable outcomes with immunosuppressive therapy.
Related Concept Videos
01:23Urinary Bladder
660
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
660
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
01:20Disorders of the Urinary System
298
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
298
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
159
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
159
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
179
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
179
01:30Inflammatory Bowel Disease II: Crohn's Disease
233
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
233