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Functional Implications of the Prosomeric Brain Model.

Luis Puelles1

  • 1Department Human Anatomy and Psychobiology and IMIB-Arrixaca (Murcia Institute for Biomedical Research), University of Murcia, LAIB Building, Avenida Buenavista s/n, El Palmar, 30120 Murcia, Spain.

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|March 28, 2024
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Summary
This summary is machine-generated.

Brain models explain brain structure and organization. The prosomeric model, based on molecular data, highlights 20 developmental units (prosomeres) for brain construction and function.

Keywords:
brain functionsbrain modelscolumnar modelmodularityneuromeric models-synthetic modelprosomeric model

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Comparative Anatomy

Background:

  • Brain models offer perspectives on brain structure, organization, and functional implications.
  • Models can be based on adult structure or developmental aspects, influencing functional interpretations.
  • Existing models contrast longitudinal (e.g., columnar) and transverse (neuromeric) organizational principles.

Purpose of the Study:

  • To review and contrast current brain models, focusing on longitudinal versus transverse approaches.
  • To examine the functional implications and challenges associated with different brain modeling strategies.
  • To highlight the significance of the molecularly-based prosomeric model.

Main Methods:

  • Comparative analysis of existing brain models, including columnar and neuromeric frameworks.
  • Examination of functional implications derived from postulated brain organizations.
  • Focus on the molecular underpinnings of the prosomeric model and its developmental units (prosomeres).

Main Results:

  • The prosomeric model posits 20 transverse prosomeres as fundamental developmental units for brain construction.
  • These metameric units possess unique molecular profiles, contributing to modularity and multiplicity in brain function.
  • Neuromeric positional information (anteroposterior and dorsoventral) is crucial for neural connections and function.

Conclusions:

  • The prosomeric model offers a powerful framework for understanding brain development and function through its modular, molecularly defined units.
  • Brain functions can be deconstructed into subfunctions supported by neuronal elements from various neuromeres.
  • Ongoing research increasingly supports the functional significance of neuromeric organization in the brain.